Long-term Neuroendocrine Effects of Iron-Deficiency Anemia in Infancy
Felt, B. T., Peirano, P., Algarin, C., Chamorro, R., Sir, T., Kaciroti, N., & Lozoff, B.
15 Feb 2012
10.1038/pr.2012.22. [Epub ahead of print]
Iron-deficiency anemia (IDA) is recognized to have long-lasting effects on neurodevelopment, but there is little research on neuroendocrine systems. This studyexamined the effects of IDA in early or later infancy on plasmacortisol and prolactin stress-response patterns for one hour after a venipuncture and catheter placement in 10-year-old healthy Chilean children. Children identified with IDA at 6 months (IDA-6; n = 13) or 12 months (IDA-12; n = 24) and who were iron sufficient at other infancy time points were compared to children who were iron sufficient (IS)at all time-points during infancy (n = 23). All children received at least 6 months of oral iron treatment in infancy. At 10 years of age, IDA-6 and IDA-12 children demonstrated altered cortisol response patterns; both showed a more immediate decline and IDA-12 children showed a blunted curvaturecompared toIS children. IDA-12 children showed significantly lower cortisol levels at 30 and 45 minutes after venipuncture and catheter placement than IS children. There were no significant differences for stress-responsive plasma prolactin patterns between groups. The results indicate that having IDA during infancy is associated with long-term neuroendocrine effects onstress-responsive cortisol patterns.